Los beneficios de la espirulina azul en la salud. Referencias bibliográficas

Los beneficios de la espirulina azul (Arthrospira platensis) en la salud

Colaboración de Evolutionary Health.

REFERENCIAS:

1. Kulshreshtha A, Zacharia AJ, Jarouliya U, Bhadauriya P, Prasad GB, Bisen PS. Spirulina in health care management. Curr Pharm Biotechnol. 2008;9(5):400-405.18855693
2. Ciferri O. Spirulina, the edible microorganism. Microbiol Rev. 1983;47(4):551-578.6420655
3. Ciferri O, Tiboni O. The biochemistry and industrial potential of Spirulina. Annu Rev Microbiol. 1985;39:503-526.3933408
4. Dillon JC, Phuc AP, Dubacq JP. Nutritional value of the alga Spirulina. World Rev Nutr Diet. 1995;77:32-46.7732699
5. Robb-Nicholson C. By the way, doctor. I read that spirulina is the next wonder vitamin. What can you tell me about it?Harv Womens Health Watch. 2006;14(3):8.
6. Godia F, Albiol J, Montesinos JL, et al. MELISSA: a loop of interconnected bioreactors to develop life support in space. J Biotechnol. 2002;99(3):319-330.12385718
7. Khan Z, Bhadouria P, Bisen PS. Nutritional and therapeutic potential of Spirulina. Curr Pharm Biotechnol. 2005;6(5):373-379.16248810
8. Lumsden J, Hall DO. Soluble & membrane-bound superoxide dismutases in a blue-green algae (Spirulina) and spinach. Biochem Biophys Res Commun. 1974;58(1):35-41.4364622
9. Mitchell GV, Grundel E, Jenkins M, Blakely SR. Effects of graded dietary levels of Spirulina maxima on vitamins A and E in male rats. J Nutr. 1990;120(10):1235-1240.2213251
10. Wang J, Wang Y, Wang Z, et al. Vitamin A equivalence of spirulina beta-carotene in Chinese adults as assessed by using a stable-isotope reference method. Am J Clin Nutr. 2008;87(6):1730-1737.18541562
11. Kapoor R, Mehta U. Utilization of beta-carotene from Spirulina platensis by rats. Plant Foods Hum Nutr. 1993;43(1):1-7.
12. Maranesi M, Barzanti V, Carenini G, Gentili P. Nutritional studies on Spirulina maxima. Acta Vitaminol Enzymol. 1984;6(4):295-304.6442827
13. Patil G, Chethana S, Madhusudhan MC, Raghavarao KS. Fractionation and purification of the phycobiliproteins fromSpirulina platensis. Bioresour Technol. 2008;99(15):7393-7396.18295479
14. Yoshikawa N, Belay A. Single-laboratory validation of a method for the determination of c-phycocyanin and allophycocyanin in Spirulina (Arthrospira) supplements and raw materials by spectrophotometry. J AOAC Int. 2008;91(3):524-529.18567296
15. Otles S, Pire R. Fatty acid composition of chlorella and spirulina microalgae species. J AOAC Int. 2001;84(6):1708-1714.11767135
16. Herrero M, Vicente MJ, Cifuentes A, Ibáñez E. Characterization by high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry of the lipid fraction of Spirulina platensis pressurized ethanol extract. Rapid Commun Mass Spectrom. 2007;21(11):1729-1738.17487827
17. Kapoor R, Mehta U. Iron status and growth of rats fed different dietary iron sources. Plant Foods Hum Nutr. 1993;44(1):29-34.
18. Kapoor R, Mehta U. Effect of supplementation of blue green algae (Spirulina) on outcome of pregnancy in rats. Plant Foods Hum Nutr. 1993;43(1):29-35.
19. Johnson PE, Shubert LE. Availability of iron to rats from Spirulina, a blue-green alga. Nutr Res. 1986;6(1):85.
20. Hayashi T, Hayashi K, Maeda M, Kojima I. Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga, Spirulina platensis. J Nat Prod. 1996;59(1):83-87.
21. Karkos PD, Leong SC, Karkos CD, Sivaji N, Assimakopoulos DA. Spirulina in clinical practice: evidence-based human applications. Evid Based Complement Alternat Med. 2008 Sep 14 [Epub ahead of print].18955364
22. Labhe RU, Mani UV, Iyer UM, Mishra M, Jani K, Bhattacharya A. The effect of spirulina in the treatment of bronchial asthma. J Nutraceutical Functional Med Foods. 2001;3(pt 4):53-62.
23. Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. J Med Food. 2005;8(1):27-30.15857205
24. Cingi C, Conk-Dalay M, Cakli H, Bal C. The effects of spirulina on allergic rhinitis. Eur Arch Otorhinolaryngol. 2008;265(10):1219-1223.18343939
25. Teas J, Hebert JR, Fitton JH, Zimba PV. Algae—a poor man's HAART?Med Hypotheses. 2004;62(4):507-510.15050097
26. Hernández-Corona A, Nieves I, Meckes M, Chamorro G, Barron BL. Antiviral activity of Spirulina maxima against herpes simplex virus type 2. Antiviral Res. 2002;56(3):279-285.12406511
27. Shih SR, Tsai KN, Li YS, Chueh CC, Chan EC. Inhibition of enterovirus 71-induced apoptosis by allophycocyanin isolated from a blue-green alga Spirulina platensis. J Med Virol. 2003;70(1):119-125.12629652
28. Ozdemir G, Karabay NU, Dalay MC, Pazarbasi B. Antibacterial activity of volatile component and various extracts of Spirulina platensis. Phytother Res. 2004;18(9):754-757.15478198
29. El-Sheekh MM, Mahmoud YA, Abo-Shady AM, Hamza W. Efficacy of Rhodotorula glutinis and Spirulina platensiscarotenoids in immunopotentiation of mice infected with Candida albicans SC5314 and Pseudomonas aeruginosa 35. Folia Microbiol (Praha). 2010;55(1):61-67.20336506
30. Subhashini J, Mahipal SV, Reddy MC, Mallikarjuna Reddy M, Rachamallu A, Reddanna P. Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562. Biochem Pharmacol. 2004;68(3):453-462.15242812
31. Li B, Gao MH, Zhang XC, Chu XM. Molecular immune mechanism of C-phycocyanin from Spirulina platensis induces apoptosis in HeLa cells in vitro. Biotechnol Appl Biochem. 2006;43(pt 3):155-164.
32. Li B, Zhang X, Gao M, Chu X. Effects of CD59 on antitumoral activities of phycocyanin from Spirulina platensis. Biomed Pharmacother. 2005;59(10):551-560.16271846
33. Roy KR, Arunasree KM, Reddy NP, Dheeraj B, Reddy GV, Reddanna P. Alteration of mitochondrial membrane potential by Spirulina platensis C-phycocyanin induces apoptosis in the doxorubicinresistant human hepatocellular-carcinoma cell line HepG2. Biotechnol Appl Biochem. 2007;47(pt 3):159-167.17274761
34. Oh SH, Ahn J, Kang DH, Lee HY. The Effect of ultrasonificated extracts of Spirulina maxima on the anticancer activity. Mar Biotechnol (NY). 2011;13(2):205-214.20405153
35. Chen T, Wong YS, Zheng W. Induction of G1 cell cycle arrest and mitochondria-mediated apoptosis in MCF-7 human breast carcinoma cells by selenium-enriched Spirulina extract. Biomed Pharmacother. 2009 Oct 27 [Epub ahead of print].19926246
36. Schwartz J, Shklar G. Regression of experimental hamster cancer by beta carotene and algae extracts. J Oral Maxillofac Surg. 1987;45(6):510-515.3108474
37. Schwartz J, Shklar G, Reid S, Trickler D. Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae. Nutr Cancer. 1988;11(2):127-134.
38. Shklar G, Schwartz J. Tumor necrosis factor in experimental cancer regression with alphatocopherol, beta-carotene, canthaxanthin and algae extract. Eur J Cancer Clin Oncol. 1988;24(5):839-850.
39. Akao Y, Ebihara T, Masuda H, et al. Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice. Cancer Sci. 2009;100(8):1494-1501.19432881
40. Grawish ME. Effects of Spirulina platensis extract on Syrian hamster cheek pouch mucosa painted with 7,12-dimethylbenz[a]anthracene. Oral Oncol. 2008;44(10):956-962.18262461
41. Grawish ME, Zaher AR, Gaafar AI, Nasif WA. Long-term effect of Spirulina platensis extract on DMBA-induced hamster buccal pouch carcinogenesis (immunohistochemical study). Med Oncol. 2010;27(1):20-28.19156551
42. Ismail MF, Ali DA, Fernando A, et al. Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina. Int J Biol Sci. 2009;5(4):377-387.19521547
43. Mathew B, Sankaranarayanan R, Nair PP, et al. Evaluation of chemoprevention of oral cancer with Spirulina fusiformis. Nutr Cancer. 1995;24(2):197-202.8584455
44. Muthuraman P, Senthilkumar R, Srikumar K. Alterations in beta-islets of Langerhans in alloxan-induced diabetic rats by marine Spirulina platensis. J Enzyme Inhib Med Chem. 2009;24(6):1253-1256.19912059
45. Mani UV, Desai S, Iyer I. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceutical Funct Med Foods. 2000;2(3):25-32.
46. Parikh P, Mani U, Iyer U. Role of spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus. J Med Food. 2001;4(4):193-199.12639401
47. ACSH News & Views. 1982;3(3):3.
48. FDA Consumer. 1981;15:3.
49. Voltarelli FA, de Mello MA. Spirulina enhanced the skeletal muscle protein in growing rats. Eur J Nutr. 2008;47(7):393-400.18807105
50. Simpore J, Kabore F, Zongo F, et al. Nutrition rehabilitation of undernourished children utilizing Spiruline and Misola. Nutr J. 2006;5:3.
51. Simpore J, Zongo F, Kabore F, et al. Nutrition rehabilitation of HIV-infected and HIV-negative undernourished children utilizing spirulina. Ann Nutr Metab. 2005;49(6):373-380.16219988
52. Park HJ, Lee YJ, Ryu HK, Kim MH, Chung HW, Kim WY. A randomized double-blind, placebo-controlled study to establish the effects of spirulina in elderly Koreans. Ann Nutr Metab. 2008;52(4):322-328.18714150
53. Kalafati M, Jamurtas AZ, Nikolaidis MG, et al. Ergogenic and antioxidant effects of spirulina supplementation in humans. Med Sci Sports Exerc. 2010;42(1):142-151.20010119
54. Nagaoka S, Shimizu K, Kaneko H, et al. A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats. J Nutr. 2005;135(10):2425-2430.16177207
55. Cheong SH, Kim MY, Sok DE, et al. Spirulina prevents atherosclerosis by reducing hypercholesterolemia in rabbits fed a high-cholesterol diet. J Nutr Sci Vitaminol (Tokyo). 2010;56(1):34-40.20354344
56. Khanam A, Rashid H. Effect of spirulina on lipid profile in patients with glomerulonephritis. Bangladesh Renal J. 2001;20:8-13.
57. Samuels R, Mani UV, Iyer UM, Nayak US. Hypocholesterolemic effect of spirulina in patients with hyperlipidemic nephrotic syndrome. J Med Food. 2002;5(2):91-96.12487756
58. Lee EH, Park JE, Choi YJ, Huh KB, Kim WY. A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Nutr Res Pract. 2008;2(4):295-300.20016733
59. Juárez-Oropeza MA, Mascher D, Torres-Durán PV, Farias JM, Paredes-Carbajal MC. Effects of dietary Spirulina on vascular reactivity. J Med Food. 2009;12(1):15-20.19298191
60. Torres-Duran PV, Ferreira-Hermosillo A, Juarez-Oropeza MA. Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary report. Lipids Health Dis. 2007;6:33.18039384
61. Rasool M, Sabina EP. Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study. J Nat Med. 2009;63(2):169-175.19093070
62. Pugh N, Ross SA, ElSohly HN, ElSohly MA, Pasco DS. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomen flos-aquae and Chlorella pyrenoidosa. Planta Med. 2001;67(8):737-742.11731916
63. Balachandran P, Pugh ND, Ma G, Pasco DS. Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice. Int Immunopharmacol. 2006;6(12):1808-1814.17052671
64. Mao TK, Van de Water J, Gershwin ME. Effect of spirulina on the secretion of cytokines from peripheral blood mononuclear cells. J Med Food. 2000;3(3):135-140.19281334
65. Hayashi O, Katayanagi Y, Ishii K, Kato T. Flow cytometric analysis of age-related changes in intestine intraepithelial lymphocyte subsets and their functional preservation after feeding mice on spirulina. J Med Food. 2009;12(5):982-989.19857060
66. Nielsen CH, Balachandran P, Christensen O, et al. Enhancement of natural killer cell activity in healthy subjects by Immulina, a Spirulina extract enriched for Braun-type lipoproteins. Planta Med. 2010;76(16):1802-1808.20560112
67. Selmi C, Leung PS, Fischer L, et al. The effects of Spirulina on anemia and immune function in senior citizens. Cell Mol Immunol. 2011;8(3);248-254.21278762
68. Torres-Durán PV, Miranda-Zamora R, Paredes-Carbajal MC, Mascher D, Díaz-Zagoya JC, Juárez-Oropeza MA. Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat. Biochem Mol Biol Int. 1998;44(4):787-793.9584992
69. Ferreira-Hermosillo A, Torres-Duran PV, Juarez-Oropeza MA. Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case series. J Med Case Reports. 2010;4(1):103.20370930
70. Karadeniz A, Cemek M, Simsek N. The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in rats. Ecotoxicol Environ Saf. 2009;72(1):231-235.18395256
71. Sharma MK, Sharma A, Kumar A, Kumar M. Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Food Chem Toxicol. 2007;45(12):2412-2419.17706852
72. Ponce-Canchihuamán JC, Pérez-Méndez O, Hernández-Muñoz R, Torres-Durán PV, Juárez-Oropeza MA. Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney. Lipids Health Dis. 2010;9:35.20353607
73. Bermejo-Bescós P, Piñero-Estrada E, Villar del Fresno AM. Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells. Toxicol In Vitro. 2008;22(6):1496-1502.18572379
74. Lu J, Ren DF, Wang JZ, Sanada H, Egashira Y. Protection by dietary Spirulina platensis against D-galactosamine–and acetaminophen-induced liver injuries. Br J Nutr. 2010;103(11):1573-1576.20102673
75. Viswanadha VP, Sivan S, Rajendra Shenoi R. Protective effect of Spirulina against 4-nitroquinoline-1-oxide induced toxicity. Mol Biol Rep. 2011;38(1):309-317.20352348
76. Mohan IK, Khan M, Shobha JC, et al. Protection against cisplatin-induced nephrotoxicity by Spirulina in rats. Cancer Chemother Pharmacol. 2006;58(6):802-808.16552571
77. Karadeniz A, Yildirim A, Simsek N, Kalkan Y, Celebi F. Spirulina platensis protects against gentamicin-induced nephrotoxicity in rats. Phytother Res. 2008;22(11):1506-1510.18690652
78. Paniagua-Castro N, Escalona-Cardoso G, Hernández-Navarro D, Pérez-Pastén R, Chamorro-Cevallos G. Spirulina (Arthrospira) protects against cadmium-induced teratogenic damage in mice. J Med Food. 2011;14(4):398-404.21254891
79. Chamorro-Cevallos G, Garduño-Siciliano L, Barrón BL, Madrigal-Bujaidar E, Cruz-Vega DE, Pages N. Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-induced mutagenicity in mice. Food Chem Toxicol. 2008;46(2):567-574.17928122
80. Misbahuddin M, Islam AZ, Khandker S, Ifthaker-Al-Mahmud, Islam N, Anjumanara. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: a randomized placebo-controlled study. Clin Toxicol (Phila). 2006;44(2):135-141.16615668
81. Chen T, Wong YS. In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. J Agric Food Chem. 2008;56(12):4352-4358.18522403
82. Dartsch PC. Antioxidant potential of selected Spirulina platensis preparations. Phytother Res. 2008;22(5):627-633.18398928
83. García-Martínez D, Rupérez FJ, Ugarte P, Barbas C. Tocopherol fate in plasma and liver of streptozotocin-treated rats that orally received antioxidants and Spirulina extracts. Int J Vitam Nutr Res. 2007;77(4):263-271.18271281
84. Gad AS, Khadrawy YA, El-Nekeety AA, Mohamed SR, Hassan NS, Abdel-Wahhab MA. Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats. Nutrition. 2011;27(5):582-589.20708378
85. Riss J, Décordé K, Sutra T, et al. Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters. J Agric Food Chem. 2007;55(19):7962-7967.17696484
86. Kim MY, Cheong SH, Lee JH, Kim MJ, Sok DE, Kim MR. Spirulina improves antioxidant status by reducing oxidative stress in rabbits fed a high-cholesterol diet. J Med Food. 2010;13(2):420-426.20210608
87. Wu LC, Ho JA, Shieh MC, Lu IW. Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts. J Agric Food Chem. 2005;53(10):4207-4212.15884862
88. Deng R, Chow TJ. Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina. Cardiovasc Ther. 2010;28(4):e33-e45.20633020
89. McCarty MF. Clinical potential of Spirulina as a source of phycocyanobilin. J Med Food. 2007;10(4):566-570.18158824
90. Shyam R, Singh SN, Vats P, et al. Wheat grass supplementation decreases oxidative stress in healthy subjects: a comparative study with spirulina. J Altern Complement Med. 2007;13(8):789-791.17983333
91. Hsiao G, Chou PH, Shen MY, Chou DS, Lin CH, Sheu JR. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem. 2005;53(20):7734-7740.16190625
92. Remirez D, González R, Merino N, Rodriguez S, Ancheta O. Inhibitory effects of Spirulina in zymosan-induced arthritis in mice. Mediators Inflamm. 2002;11(2):75-79.
93. Rasool M, Sabina EP, Lavanya B. Anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in mice. Biol Pharm Bull. 2006;29(12):2483-2487.17142986
94. Kumar N, Singh S, Patro N, Patro I. Evaluation of protective efficacy of Spirulina platensis against collagen-induced arthritis in rats. Inflammopharmacology. 2009;17(3):181-190.19390977
95. Gupta S, Hrishikeshvan HJ, Sehajpal PK. Spirulina protects against rosiglitazone induced osteoporosis in insulin resistance rats. Diabetes Res Clin Pract. 2010;87(1):38-43.19896232
96. Bachstetter AD, Jernberg J, Schlunk A, et al. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PLoS One. 2010;5(5):e10496.20463965
97. ALSUntangled Group. ALSUntangled No. 9: Blue-green algae (Spirulina) as a treatment for ALS. Amyotroph Lateral Scler. 2011;12(2):153-155.21323493
98. Baicus C, Baicus A. Spirulina did not ameliorate idiopathic chronic fatigue in four N-of-1 randomized controlled trials. Phytother Res. 2007;21(6):570-573.17335116
99. Thaakur S, Sravanthi R. Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats. J Neural Transm. 2010;117(9):1083-1091.20700612
100. Yang L, Wang Y, Zhou Q, et al. Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization. Mol Vis. 2009;15:1951-1961.19784394
101. Lu HK, Hsieh CC, Hsu JJ, Yang YK, Chou HN. Preventive effects of Spirulina platensis skeletal muscle damage under exercise-induced oxidative stress. Eur J Appl Physiol. 2006;98(2):220-226.16944194
102. Qishen P, Guo BJ, Kolman A. Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studied by using the micronucleus test. Toxicol Lett. 1989;48(2):165-169.2505406
103. Klingler W, Kreja L, Nothdurft W, Selig C. Influence of different radioprotective compounds on radiotolerance and cell cycle distribution of human progenitor cells of granulocytopoiesis in vitro. Br J Haematol. 2002;119(1):244-254.12358931
104. Kraigher O, Wohl Y, Gat A, Brenner S. A mixed immunoblistering disorder exhibiting features of bullous pemphigoid and pemphigus foliaceus associated with Spirulina algae intake. Int J Dermatol. 2008;47(1):61-63.18173606
105. Mazokopakis EE, Karefilakis CM, Tsartsalis AN, Milkas AN, Ganotakis ES. Acute rhabdomyolysis caused by Spirulina (Arthrospira platensis ). Phytomedicine. 2008;15(6-7):525-527.18434120
106. Iwasa M, Yamamoto M, Tanaka Y, Kaito M, Adachi Y. Spirulina-associated hepatotoxicity. Am J Gastroenterol. 2002;97(12):3212-3213.12492223
107. Rawn DF, Niedzwiadek B, Lau BP, Saker M. Anatoxin-a and its metabolites in blue-green algae food supplements from Canada and Portugal. J Food Prot. 2007;70(3):776-779.17388076
108. Jiang Y, Xie P, Chen J, Liang G. Detection of the hepatotoxic microcystins in 36 kinds of cyanobacteria Spirulina food products in China. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25(7):885-894.18569007
109. Wu JF, Pond WG. Amino acid composition and microbial contamination of Spirulina maxima, a blue-green alga, grown on the effluent of fermented animal wastes. Bull Environ Contam Toxicol. 1981;27(2):151-159.6794684
110. Lee AN, Werth VP. Activation of autoimmunity following use of immunostimulatory herbal supplements. Arch Dermatol. 2004;140(6):723-727.15210464
111. Grobler L, Siegfried N, Visser ME, Mahlungulu SSN, Volmink J. Nutritional interventions for reducing morbidity and mortality in people with HIV. Cochrane Database Syst Rev. 2013;2:CD004536.2345055410.1002/14651858.CD004536.pub3
112. Torres-Durán PV, Ferreira-Hermosillo A, Ramos-Jiménez A, Hernández-Torres RP, Juárez-Oropeza MA. Effect of Spirulina maxima on postprandial lipemia in young runners: a preliminary report. J Med Food. 2012;15(8):753-757.22738038
113. Jensen GS, Attridge VL, Beaman JL, Guthrie J, Ehmann A, Benson KF. Antioxidant and anti-inflammatory properties of an aqueous cyanophyta extract derived from Arthrospira platensis: contribution to bioactivities by the non-phycocyanin aqueous fraction. J Med Food. 2015;18(5):535-541.25764268
114. Serban MC, Sahebkar A, Dragan S, et al. A systematic review and meta-analysis of the impact of spirulina supplementation on plasma lipid concentrations. Clin Nutr. 2016;35(4):842-851.
115. Szulinska M, Gibas-Dorna M, Miller-Kasprzak E, et al. Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study. Eur Rev Med Pharmacol Sci. 2017;21:2473-2481.28617537